(Français) 20èmes journées Françaises de l’Epilepsie (JFE)

From Monday 9th October 2017 at 11:00
To Thursday 12th October 2017 at 16:00

Location : Palais du Pharo 58, Boulevard Charles Livon Marseille

Sorry, this entry is only available in Français.

INS Topical Seminar – Jean-Rémi King (New York)

From Monday 28th August 2017 at 14:00
To Monday 28th August 2017 at 15:30

Location : INS new seminar room on 5th floor Faculty of medecine, La timone Marseille

"Identifying the neural architecture of human cognition"

What computations are specific to human cognition? Are they supported by a particular neural architecture? How might such an architecture supplement the design of machine learning algorithms? Here, I will argue that the recent developments in 1) machine learning and 2) temporally-resolved neuroimaging offer a new opportunity to address these foundational issues. In particular, I will show how we can track the unfolding of complex cognitive processes, such as perceptual decision making and speech comprehension, and identify what representations the human brain encodes, selects, and maintains at each instant in time. The present studies show how we can isolate and track a multitude of processing stages reminiscent of deep neural networks. Finally, I outline a few promising research directions to investigate parallel, serial, and recursive computations in syntactic processing and conceptual composition. I argue that the present research program will pave the way to integrate the disciplines of biological and artificial cognition.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Topical Seminar – Christine Métin (Paris)

From Thursday 13th July 2017 at 14:00
To Thursday 13th July 2017 at 15:30

Location : INS new seminar room on 5th floor Faculty of medecine, La timone Marseille

"Cellular mechanisms regulating the cortical distribution of GABAergic interneurons"

The p21 activated kinases (PAKs) are activated by Rac1 and Cdc42 and regulate the dynamics and contractility of the acto-myosin cytoskeleton, and the turnover of adhesive contacts. Mutations in one isoform, PAK3, are responsible in humans of X-linked non-syndromic intellectual disability. Pak3 is expressed in tangentially migrating interneurons in the developing cortex. By overexpressing mutants that mimic human mutations (kinase dead or defective for GTPase binding) or a constitutively active mutant, we have analyzed the influence of PAK3 activity on the morphology, dynamic behavior and on the trajectories of migrating interneurons in the developing cortex.

Christine Métin, DR2 INSERM, co-leads with P. Gaspar the team ”Developmental mechanisms of brain disorders” at Institut du Fer à Moulin (IFM) in Paris. With her group, C. Métin analyzes the cellular mechanisms that regulate the long distance migration of cortical interneurons from the basal forebrain to the developing cortex. She uses in vivo models to study how the migratory defects of interneurons alter their final distribution in the cortical target. In collaboration with the team of C. Bernard, she studies the consequences of interneuron migratory defects on the activity of cortical networks.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

1st AM*IDEX CompNeuro Days

From Wednesday 12th July 2017 at 9:00
To Thursday 13th July 2017 at 17:00

Location : INMED, Luminy

The aim of this workshop is to gather researchers active in the field of general computational neuroscience to illustrate the diversity of its approaches and the richness of cooperation between theorists and experimentalists
and all this in an informal atmosphere favourable to discussions. 

PhD students are warmly welcome and will be given the opportunity to present their research (not necessarily computational, on the contrary!) in Blitz oral presentations (ca. 5 min) and/or poster.

*** The registration is open and compulsory (deadline July 2nd), but free ***

In addition the students willing to present their result should send an email with a short title and abstract, name of the supervisor to the organisers:
Alessandro Torcini (torcini@gmail.com), David Angulo Garcia (david.angulo-garcia@univ-amu.fr), Demian Battaglia (demian.battaglia@univ-amu.fr)

They will then be informed of the type of presentation assigned to them (Blitz oral or poster). There are only limited slots available for oral, so priority will be given to thematic diversity.

List of speakers:
• Nicolas Brunel (Chicago, USA),
• Frederic Chavane (Marseille, France)
• Daniel Durstewitz ( Mannheim, Germany)
• Boris Gutkin (Paris, France)
• Vincent Hakim (Paris, France)
• David Hansel (Paris, France)
• Viktor Jirsa (Marseille, France)
• Anna Levina (Klosterneuburg, Austria)
• Nicolas Mallet (Bordeaux, France)
• Arnaud Malvache (Marseille, France)
• Gianluigi Mongillo (Paris, France)
• Alfonso Renart (Lisbon, Portugal)
• Petra Ritter (Berlin, Germay)


A*Midex, INMED, Institut de Neurosciences des Systèmes, Institut de Neurosciences de La Timone, EPINEXT, PhD Program in Integrative and Clinical Neurosciences, Mediterranean Neuroscience Society, Marie Curie Actions, Società Italiana Caos e Complessità

INS Epinext Seminar – Randy McIntosh (Toronto)

From Tuesday 11th July 2017 at 14:00
To Tuesday 11th July 2017 at 15:30

"Why Dynamics are Vital for Brain Health"

Brain networks have a rich functional repertoire. The architecture of the brain is such that communication between regions shows differing time delays dependent partly on distance. These time delays, considered in the context of the spatial distribution of regions, establish a space-time structure that characterizes the potential network dynamics that can be supported by a given brain. We have shown that the this space-time structure sculpts the dynamics in a principled manner during maturation and senescence. In childhood, the dynamics change most at slower timescales favouring distributed networks. In healthy ageing there appears to be a shift in dominant timescales so as to bias the dynamics to local networks. Clinical studies suggest that if such a shift in preferred timescales does not happen cognitive dysfunction ensues. These studies reinforce the need to carefully consider brain dynamics as a more sophisticated index of brain health and dysfunction.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Keynote Seminar – Joachim Gross (Glasgow)

From Friday 30th June 2017 at 14:00
To Friday 30th June 2017 at 15:30

Location : INS new seminar room on 5th floor Faculty of medecine, La timone Marseille

"Cycles of coordination and communication in the human brain"

Invasive and noninvasive studies in humans under physiological and pathological conditions converged on the suggestion that brain oscillations are related to cognitive processes such as sensory representations, attentional selection, and dynamical routing/gating of information. I will present recent studies that aim to further our understanding of the computational role of brain oscillations in three different areas: First, to what extent are brain oscillations regional specific and can account for computational specialisation of individual brain areas. Second, are there preferred rhythms that link perception and action and how are they expressed in behaviour. Third, what is the evidence that oscillations play a causal role in perception and action.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Topical Seminar – Francesco Cardinale (Italy)

From Friday 23rd June 2017 at 14:00
To Sunday 23rd April 2017 at 15:30

Location : Salle de réunion du service de neurochirurgie (5eme étage, Hôpital Timone Adultes) La Timone Hospital Marseille

"Image guidance to plan SEEG strategy and trajectories"

The processing of neuro-images can be helpful in the field of epilepsy surgery. At “Claudio Munari” Center, Milan, we have developed two original workflows to assist both the planning and the robotic implantation of SEEG electrodes. SUPR-FLAIR analysis can lead to lesion detection and epilepsy network visualization in MRI-negative patients. The other image processing pipeline is aimed at planning safe and accurate SEEG trajectories. Key points and clinical results will be presented.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Keynote Seminar – Charlotte Jacquemot (Paris)

From Thursday 8th June 2017 at 14:00
To Thursday 8th June 2017 at 15:30

Location : INS new seminar room on 5th floor Faculty of medecine, La timone Marseille

"Translational research in psycholinguistic: how basic research informs clinical research and vice versa"

Basic and applied research are traditionally conceived as fundamentally different. Applied research is used to answer a specific question that has a direct application, for instance in the medical field; on the contrary, basic research is motivated purely by a desire to expand theoretical knowledge. In my talk, I will argue that tight interactions between basic and applied research – that is translational research- can be fruitful, and show how basic research can inform clinical research and vice versa. I will focus on language processing and its impairments in neurological patients (stroke and neurodegenerative patients) and present two new tools issued from translational research that can be used to improve patients’ care.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Topical Seminar – Adrian Ponce Alvarez (Barcelona)

From Thursday 18th May 2017 at 14:00
To Thursday 18th May 2017 at 15:30

Location : INS new seminar room on 5th floor Faculty of medecine, La timone Marseille

"Reduced large-scale models of spontaneous and task brain activity"

Spatial patterns of coherent activity across different brain regions have been identified during the resting-state fluctuations of the brain. The question of how such resting-state functional connectivity (FC) emerges from the brain’s anatomical connections has motivated several experimental and computational studies to understand structure/function relationships. Moreover, it has been shown that resting-state activity is not stationary but shows complex slow temporal dynamics, reflecting the transient formation and dissolution of multiple sub-networks. Theoretical models allow us to investigate explicitly how the interplay between neural dynamics and underlying anatomical connectivity give rise to spatiotemporally organized activity. Using reduced large-scale models, which are mathematical approximations of more biologically plausible models, and analyses of fMRI activity I will show how simple dynamics embedded in the human cerebral connectome can explain i) the emergence of FC, ii) the formation of transient sub-networks, iii) the building up of state-dependent effective connectivity under task conditions, and, finally, iv) I will discuss the models’ functional implications in terms of the information capacity of brain networks and the transmission of stimulus-related information.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

The Virtual Brain Node 5 | 2-day Training Workshop in Marseille, 15th-16th May 2017

From Monday 15th May 2017 at 08:30
To Tuesday 16th May 2017 at 18:00

Location : Pedagogical Building (the yellow one), Room 202 Faculty of Medicine at La Timone, 27 Boulevard Jean Moulin Marseille, France

We would like to invite interested students and researchers to the upcoming The Virtual Brain Node 5 workshop held at Faculty of Medicine (yellow building) in Marseille, on 15th - 16th May 2017.

The workshop is dedicated to a theoretical and hands-on understanding of large-scale brain network modeling using the open source neuroinformatics platform The Virtual Brain (TVB). For the first time this workshop will be held over 2 days and will go more in depth regarding the hands-on modeling sessions along explicit use cases from resting state studies and clinical applications to epilepsy and stroke. Also for the first time we will offer in-depth training of fitting virtual brain models to human imaging data. 
The Virtual Brain simulation environment enables the biologically realistic modeling of network dynamics using connectome-based approaches across different brain scales. Personalized brain network models can be derived from an individual’s MRI data. Configurable brain network models generate macroscopic neuroimaging signals including functional MRI, intracranial and stereotactic EEG, surface EEG and MEG for single subjects. TVB researchers from different backgrounds can benefit from an integrative software platform including a supporting framework for data management (generation, organization, storage, integration and sharing) and a simulation core written in Python. 

Workshop format: lectures and hands-on tutorials. Participants are encouraged to bring their own data to work on.

Workshop program overview:

- Theoretical background of large scale brain network modeling
- Architecture of The Virtual Brain (TVB)
- Interacting with TVB using GUI and Python interface
- Preprocessing neuroimaging data, or how to obtain a TVB dataset
- Fitting the brain model parameters to the functional data
- Modeling resting state network dynamics in fMRI
- Modeling stroke and recovery
- Modeling epilepsy and surgical interventions
- Modifying TVB code and implementing new features
- Bring your own data hands-on sessions: preprocessing and simulations

Further information and the registration form can be found HERE.

You can find the detailed program and other tips on the official event page.

Registration will be closed on April 20th.

For any questions please contact Viktor Sip (viktor.sip@univ-amu.fr).

Powered by:

TVB_logo            Epinext_logo

INS Keynote Seminar – Christian Jutten (Grenoble)

From Thursday 27th April 2017 at 14:00
To Thursday 27th April 2017 at 15:30

Location : INS new seminar room on 5th floor Faculty of medecine, La timone Marseille

"Source Separation: Principles and Applications on Biomedical Signals"

In the first part of the talk, I will present simple and comprehensive principles of source separation, as well as some results including independent component analysis, and methods based on second order statistics and on sparsity. The second part will illustrate, and sometimes extend methods presented in the first part, on various applications in biomedical signals, especially MEG, EEG and ECG.

Keywords: source separation, independent component analysis, joint diagonalisation, sparse sources, biomedical applications

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Topical Seminar – Adrien Meguerditchian (LPC, Marseille)

From Thursday 6th April 2017 at 14:00
To Thursday 6th April 2017 at 15:30

Location : New INS Seminar Room, La Timone, Faculty of Medicine, 5th floor, red wing Marseille


"On the gestural origins of language: Communication in primates & hemispheric specialization of the brain."

Given the phylogenetical proximity between human and nonhuman primates, research on the communicative, motor and cognitive systems of our primate cousins could help us determining the prerequisites of some language properties inherited from our common ancestor. Whereas some researchers have suggested that language resulted from the evolution of the vocal system, this theory is now challenged by a growing number of authors supporting the “gestural origins” view. Such an alternative theory underlies the fundamental role of gestural communication in the first phylogenetic roots of language.

Such a gestural theory finds support in the considerable evidence of tight links between language organization in humans and gestures including co-speech gestures, sign language in deaf people, and preverbal pointing gestures in infants. Moreover, research has reported potential continuities between the communicative gestural system in nonhuman primates, its lateralization and several fundamental properties of language, such as intentionality, learning flexibility, referential properties and left-hemispheric specialization of the brain. In the present communication, I will review our previous and on-going works on the gestural and vocal behaviors in nonhuman primates, laterality as well as recent findings in anatomical brain imaging in chimpanzees and baboons. I will try to demonstrate that these data in ethology, comparative psychology and neurosciences speak not only for a specific significance of communicative gestures in the course of the language evolution and its hemispheric brain specialization but also for the "bimodal" origin of language with the progressive integration of the oro-facial and vocal control into the gestural intentional system.


For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)


INS/Epinext Topical Seminar – Marta Favali (Paris)

From Friday 17th March 2017 at 11:00
To Friday 17th March 2017 at 12:30

Location : New INS Seminar Room, La Timone, Faculty of Medicine, 5th floor (red wing), Marseille

"Formal models of visual perception based on cortical architectures"

I will show the integration of geometric models of visual perception with dimensionality reduction techniques. Starting from the model of association fields introduced by Citti and Sarti [2], which gives a justification of perceptual completion based on the functionality of the primary visual cortex (V1), it is possible to model the cellular connectivity by solving systems of stochastic differential equations as described in [9] and [1], obtaining the probability density that is the probability of connection between simple cells in V1 [1]. Starting from these kernels, the problem of grouping is faced by means of spectral analysis of suitable affinity matrices [2,7]. For the numerical simulations, I have consider particularly Kanizsa figures as clear examples of problems of visual perception [5], and retinal images, to afford problems of grouping during the tracking of blood vessels [4]. Finally I will show a comparison between the results obtained through these models with functional data fMRI, in order to afford the problem of identification and reconstruction of images from fMRI activity [3,6,8].

[1] D. Barbieri, G. Citti, G. Cocci, A. Sarti, A cortical-inspired geometry for contour perception., 2013.
[2] G. Citti and A. Sarti, A cortical based model of perceptual completion in the roto-translation space., Journal of Mathematical Imaging and Vision, 24(3):307-326, 2006.
[3] K. N. Kay, T. Naselaris, R. J. Prenger, and J. L. Gallant. Identifying natural images from human brain activity. Nature, 452(7185): 352-355, 2008.
[4] M. Favali, S. Abbasi-Sureshjani, B. H. Romeny, and A. Sarti. Analysis of vessel connectivities in retinal images by cortically inspired spectral clustering. Journal of Mathematical Imaging and Vision, 56(1):158-172, 2016a.
[5] M. Favali, G. Citti, A. Sarti, Local and global gestalt laws: A neurally based spectral approach, Neural Computation, February 2017, Vol. 29, No. 2, Pages: 394-422.
[6] T. Naselaris, R. J. Prenger, K. N Kay, M. Oliver, and J. L. Gallant. Bayesian reconstruction of natural images from human brain activity. Neuron, 63(6):902-915, 2009.
[7] A. Sarti, G. Citti, The constitution of visual perceptual units in the functional architecture of V1, Journal of computational neuroscience, 38(2):285–300, 2015.
[8] B.Thirion, E. Duchesnay, E. Hubbard, J. Dubois, J. Poline, D. Lebihan, and S. Dehaene. Inverse retinotopy: inferring the visual content of images from brain activation patterns. Neuroimage, 33(4):1104-1116, 2006.
[9] L.R. Williams, D.W. Jacobs, Stochastic completion fields., ICCV Proceedings, 1995.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Topical Seminar – Christian Kell (Frankfurt)

From Friday 17th March 2017 at 14:00
To Friday 17th March 2017 at 15:30

Location : INS new seminar room on 5th floor Faculty of medecine, La timone Marseille

"Time after time - endogenous neural clocks serving information coding and perception"

Topology has prompted decades of Neuroscientists to focus on the spatial aspects of brain function. Research on the temporal aspects of neural processing like event-related potentials has revealed neural processing cascades that are easily interpretable by the linearly reasoning mind. It is only within the last decades that the role of neural oscillations in cognition has been tentatively discovered.
In this talk I will present data on endogenous rhythmic, predictable cyclic changes in neural activity covering two different extremes of the temporal spectrum. First, electrocorticography recordings during verbal working memory tasks reveal that neural oscillations, particularly in the beta band, endogenously code linguistic information, which argues for an active role for neural oscillations in coding language. Second, the results of a functional imaging study investigating the effects of Time of day on brain activity identify suppression of spontaneous brain activity in sensory cortices at times of civil twilight as an endogenous mechanism that improves close-to-threshold perception at those times of day.
The brain's capacity to actively structure time on multiple scales by means of oscillations and aligning those with rhythmic regularities in the environment seems to constitute a scale-free characteristic of neural processing underlying human cognition.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Keynote Seminar – Sylvain Baillet (Montreal)

From Thursday 2nd March 2017 at 14:00
To Thursday 2nd March 2017 at 15:30

Location : New INS Seminar Room, La Timone, Faculty of Medicine, 5th floor (red wing), Marseille

"Possible mechanisms underlying the polyrhythmic activity of the brain: from rest to perception."

One broad objective in neuroscience is to comprehend the mechanisms of large-scale, oscillatory neural dynamics: how they enable functions by shaping communication in brain networks, and how the earliest detection of their alterations in disease can contribute to improved healthcare prevention and interventions. To contribute toward this goal, our approach is to combine imaging methods and experimental neuroscience with computational and disease models, neuromodulation techniques, and translational arms to the clinic and industry. Our rationale is that the ubiquitous polyrhythmic activity of the brain has been approached empirically, with underlying mechanisms that remain not understood.
This hinders our comprehension of how 1) perception and behaviour emerge from brain network activity, and 2) the pathophysiological developments of brain and mental-health disorders increasingly studied as network diseases, affect large-scale neural communication.

These difficult questions require a bottom-up approach: We aim to understand how basic physiological factors of neural integrity and function shape the dynamical structure of oscillatory brain rhythms, such as their interdependence across multiple frequencies through cross-frequency coupling. These phenomena represent a deep source of uncharted markers of neural excitability, activity and connectivity. I will illustrate these principles with our latest results concerning the resting brain, multimodal perception and pathophysiological markers of epilepsy and neurodegenerative syndromes.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Keynote Seminar – Valentin Wyart (Paris)

From Thursday 23rd February 2017 at 14:00
To Thursday 23rd February 2017 at 15:30

Location : New INS Seminar Room, La Timone, Faculty of Medicine, 5th floor (red wing), Marseille

"Premature, self-confirmatory commitment to uncertain decisions during pharmacologically induced transition to psychosis: a placebo-controlled, double-blind EEG study in healthy human subjects"

In schizophrenia, early stages of psychosis are characterized by a state of pathological uncertainty (or 'strangeness') which is difficult to study in patients due to its transitional nature. Therefore, the alterations of mental processes which lead to full-blown delusions remain largely unknown. Here we studied a pharmacological model of this condition using ketamine, an NMDA receptor antagonist, in healthy subjects performing a decision-making task based on ambiguous probabilistic cues.
Computational modeling of subjects' behavior under ketamine revealed a decrease in the precision of inference - the mental process of interpreting and accumulating evidence during decision-making. The analysis of simultaneously recorded EEG signals provided support for this selective alteration, by showing a degraded neural coding of the evidence provided by individual cues. Furthermore, upcoming decisions could be decoded earlier from EEG signals under ketamine, and evidence inconsistent with upcoming decisions were down-weighted in the inference process.
Together, these findings indicate a premature, self-confirmatory commitment to uncertain decisions under ketamine, a selective alteration of decision-making which could explain the stabilization of aberrant beliefs characteristic of psychosis.

For any question, feel free to contact:
Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

Morning’s meeting: public information and sharing on epilepsy

From Saturday 4th February 2017 at 09:00
To Saturday 4th February 2017 at 12:00

Location : Hôpital de la Timone - Amphithéâtre HA1 264 Rue Saint Pierre Marseille

Le service de Neurophysiologie Clinique dirigé par le Prof. Fabrice Bartolomei organise une matinée d'information et d’échanges sur l’épilepsie prévue le 04/02/2017 à l'Amphi HA1 de l'Hôpital Timone. L’organisation de cette réunion compte avec le soutien d’Epilepsie France (www.epilepsie-france.com) et de la FHU Epinext (www.epinext.org) et est sponsorisé par le laboratoire UCB.

Il s'agit d'une réunion grand public dédiée surtout aux patients et leurs familles où on présentera les réseaux de soins en épileptologie, c’est qu’une crise d’épilepsie, quels sont les progrès qui ont été fait en génétique, comment on développe un médicament antiépileptique et une discussion autour des conflits d’intérêts. Cette matinée est ouverte aussi au personnel du corps médical ou des chercheurs qui pourraient être intéressés par l’épilepsie.

Vous trouverez ci-dessous le programme et le plan d’accès à la Faculté de Médecine Timone.



L’inscription est gratuite mais obligatoire jusqu’au 31/01/2017 sur ce site :  https://fr.surveymonkey.com/r/9VTWRG2

INS Keynote Seminar – Maria SANCHEZ-VIVES (Barcelona)

From Thursday 2nd February 2017 at 14:00
To Thursday 2nd February 2017 at 16:00

Location : New INS Seminar Room, La Timone, Faculty of Medicine, 5th floor, red wing Marseille

Abstract: "Slow oscillations dominate the activity of both the intact and the isolated cerebral cortex and present similar characteristics across different cortical areas. These properties led to the suggestion that slow oscillations are the default emergent activity of the cortical network (1). Such default activity is a low complexity state that integrates neuronal membrane, synaptic activity and connectivity properties of the cortex. It provides a gauge of the state of the underlying network, being sensitive to variations of parameters such as ionic levels (2), temperature (3) or excitatory/inhibitory balance (4). It also serves the identification of pathological changes, having been used to characterize transgenic models of neurological diseases (5).

This cortical default activity is shaped and it acts as a powerful attractor leading to a breakdown of cortical connectivity and complexity. Getting out of this attractor is necessary for the brain to recover the levels of complexity associated with conscious states.

1. Sanchez-Vives, & Mattia (2014). Slow wave activity as the default mode of the cerebral cortex. Arch Ital Biol, 152, 147

2. Sancristóbal et al (2016). Collective stochastic coherence in recurrent neuronal networks. Nature Physics, 12(9), 881

3. Reiget et al (2010). Temperature modulation of slow and fast cortical rhythms. Journal of neurophysiology, 103(3), 1253

4. Sanchez-Vives et al. (2010). Inhibitory modulation of cortical up states. Journal of neurophysiology, 104(3), 1314

5. Ruiz-Mejias, et al. "Overexpression of Dyrk1A, a down syndrome candidate, decreases excitability and impairs gamma oscillations in the prefrontal cortex." Journal of Neuroscience 36.13 (2016): 3648.

INS Keynote Seminar – Bruno CAULI (Paris)

From Thursday 12th January 2017 at 14:00
To Thursday 12th January 2017 at 15:30

Location : New INS seminar room, La Timone, Faculty of medecine, 5th floor (red wing), Marseille

"Neurogenic control of neurovascular coupling".

The cerebral cortex comprises diverse areas involved in perception, movement or cognition. In spite of this functional diversity, the cortical network is formed with the repetition of a microcircuit containing excitatory and inhibitory neuronal types. The activity of this microcircuit, its local cerebral blood flow and metabolism are tightly coupled to match the increased energy needs occurring during neuronal processing. This neurovascular and neurometabolic coupling, essential to normal brain function and integrity, is also the physiological basis of the hemodynamic contrasts widely used to map neuronal activity in health and disease.

Despite this physiopathological importance, the cellular and molecular mechanisms of neurovascular coupling remain poorly understood. Presumably because of the large diversity that characterizes cortical neurons (Ascoli et al., 2008, DeFelipe et al., 2013), the contribution of neuronally-driven mechanisms of neurovascular coupling has been largely overlooked. A major goal of our group is to understand how the microcircuit controls its own energy supply via interactions with the glio-vascular network. Using ex vivo and in vivo approaches our team pioneered the differential contribution of neuronal types in neurovascular coupling by showing that peculiar subsets of cortical neurons control the microvasculature (Cauli et al., 2004; Rancillac et al., 2006; Lecrux et al., 2011; Lacroix et al., 2015). These findings indicate that neurovascular coupling is achieved by specialized cell types. They also suggest that the hemodynamic contrasts visualized by modern imaging techniques only reflect the recruitment of these cells types. 

For any question, feel free to contact: 

Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (bnmorillon@gmail.com)

INS Keynote Seminar – Francesca SARGOLINI (Marseille)

From Thursday 1st December 2016 at 14:00
To Thursday 1st December 2016 at 16:00

Location : New INS seminar room, La Timone, Faculty of medecine, 5th floor (red wing), Marseille

"Entorhinal cortex and spatial navigation".

The ability to find our way in space relies on specialized cell populations, whose activity collectively provide a dynamic representation of self-localisation relative to external landmarks and goals. This cell network includes place cells in the hippocampus, head-direction cells in different cortical and subcortical areas, grid cells in the entorhinal cortex, and border/boundary cells in the parahippocampal areas. It is presently unknown which is the nature of the representation provided by each cell type and how they interact to support spatial navigation. For example, grid cells are spatially selective neurons whose firing fields form a regular hexagonal pattern that is relatively invariant across different environments. This periodic organization has inspired a number of models and theories suggesting a primary role of this cell population in self-motion-based navigation. In accordance with this hypothesis, we have recently shown that lesions of the entorhinal cortex impairs rats’ ability to estimate distances and directions on the bases on the information generated exclusively by their movements (i.e. in the absence of external landmarks). However, we have also shown that the metric properties of the grid cell map strongly rely on the external environment. In particular, changing the environment from 2D to 1D provokes drastic modifications of the map, whereas the activity from other place-selective cells (head-direction cells and border cells) is unmodified. These results demonstrate that the external information (and not only the self-motion cues) are primordial to establish the grid cell spatial activity, thus questioning their selective role in self-motion-based navigation.

For any question, feel free to contact: 

Demian Battaglia (demian.battaglia@univ-amu.fr) or Benjamin Morillon (benjamin.morillon@unvi-amu.fr)