Integrating academic and clinical approaches
The Institut de Neurosciences des Systèmes (INS, UMR1106) is a multidisciplinary research institute of Inserm and Aix-Marseille University located on La Timone Campus in Marseille. INS core faculty is composed of members of academic (Faculty) and clinical (APHM) institutions, as well as Inserm and CNRS researchers. The INS research has been developed around a common concept, the dynamic brain, integrating experimental, theoretical and clinical approaches towards the understanding of brain function and dysfunction.
INS houses a wide range of state-of-the-art facilities of brain research, which includes the MEG facility, the TMS-EEG facility with a Brain Navigation system, various electrophysiology laboratories, an epileptic patient unit, and the Virtual Brain platform. INS researchers perform research across species ranging from the rodent, through the monkey to the human brain to uncover the mechanisms underlying the functioning of the healthy brain and its disorders, notably epilepsy as the paradigmatic dynamic brain disease. The INS research is based on both traditional approaches, as well as novel approaches that carry a high-risk, but promise a high-impact (see for instance the projects EpiMonk and Virtual Brain). Such innovative projects can only be realized within a unique environment as offered by INS, in which many and distinct competencies ranging from Applied Mathematics through structural/functional brain imaging to Clinical Epilepsy are assembled in the same unit.
INS is strongly supported by both the academic (Medical Faculty) and clinical (APHM) institutions on La Timone Campus.
Making a donation
Your generosity will help these research scientists to progress knowledge in neuroscience and brain function, to fight against diseases such as epilepsy, and to develop new therapeutical strategies.
Your donations will be paid in full to the research laboratory or to a given team (no running costs and exemption for Inserm from gift tax, pursuant to Article 795-2° of the French General Tax Code). Please fill the form (70.5 ko) and do not forget to specify if your donation concerns a given team or the whole laboratory.
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Congratulations to Marisa who successfully defended her PhD entitled ”Epidynamics: Seizures in the Unfolding of a High Codimension Singularity.”
Check our new paper in Journal of Neuroscience :: Ferraris M, Ghestem A, Vicente AF, Nallet-Khosrofian L, Bernard C, Quilichini PP. The nucleus reuniens controls long-range hippocampo-prefrontal gamma synchronization during slow oscillations. Journal of Neuroscience 19 February 2018, 3058-17; DOI: https://doi.org/10.1523/JNEUROSCI.3058-17.2018 ABSTRACT Gamma oscillations are involved in long-range coupling of distant regions which support various cognitive operations. Here we show in adult male rats that synchronized bursts of gamma...
A classical marker of epileptogenic tissues is the interictal epileptiform discharge. Recently, is has been proposed to use high frequency oscillations as a more specific marker. We have shown in our recent publication in Annals of Neurology by Roehri and colleagues that a promising strategy is in fact to combine the two markers in order to improve both sensitivity and specificity. https://www.ncbi.nlm.nih.gov/pubmed/29244226
Epilepsy: Building Personalised Models of the Brain Human Brain Project scientist Viktor Jirsa is the head of a team creating personalised brain models for patients with intractable epilepsy. He explains the process and how the HBP’s brain models and cross-displinary collaborations are central to a new way of targeting epilepsy surgery.
Le cortex moteur aide à mieux entendre Le cortex moteur et le cortex auditif travaillent de concert pour entendre un son ou une parole en environnement bruyant. L’équipe Inserm qui vient de le prouver montre que le premier identifie le rythme du son et aide le second à mieux l’entendre.
Contexte : le projet EPINOV Ce projet est mené par un consortium national composé de cliniciens, de chercheurs et de partenaires industriels intéressés à améliorer le pronostic chirurgical de l’épilepsie en utilisant une modélisation cérébrale à grande échelle basée sur des données de patients épileptiques individuels. Un essai multicentrique prospectif et randomisé va être mené auprès de sujets souffrant d’épilepsie pharmacorésistante. Cet essai nécessite la gestion de données structurées sur le modèle relationnel et des...
Summary The Theoretical Neuroscience Group (Head: Viktor Jirsa) is seeking to fill a post-doctoral position in the context of the project EPINOV to work on statistical & dynamical modeling of seizure propagation using personalized brain modeling and neuroinformatics approaches on a cohort of hundreds of epilepsy patients. EPINOV is one of 10 large-scale projects selected in the 3rd round of French scientific excellence program «RHU» managed by the National Research Agency (ANR). The aim of the EPINOV project is to significantly...
Post-doc in Neuroscience PhysioNet Team, Institute of System Neuroscience (INS), UMR1106 AMU-Inserm, Marseille, FRANCE One postdoc position (at least one year) is offered at INS in the Physionet team in the field of Alzheimer, starting end of 2017 – beginning of 2018. Caffeine exposure in utero as a risk factor for the development of Alzheimer’s disease We have previously shown that in utero caffeine exposure through the dam (equivalent of 2-3 espressos in humans) delays the insertion of some GABA neuron populations in the hippocampus...
Two PhD positions in Neuroscience PhysioNet Team, Institute of System Neuroscience (INS), UMR1106 AMU-Inserm, Marseille, FRANCE Two 3-year PhD positions are offered at INS in the field of epilepsy, starting before the end of 2017.They are part of the M-GATE ITN project 765549, which is financed by EU and offers high level salary. Students will be able to travel to M-GATE EU partners and learn complemetary techniques, exposing them to a beyond the state of the art multi- and trans-disciplinary project Position 1. Disruption of memory circuit...
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