PhysioNet Team Member

Yuri Zilberter

Yuri Zilberter, DR Inserm
PhysioNet


Email:

Phone number:
+33 4 91 29 98 11



Personal:    Born January 1, 1953, married, three sons.

Website: NeuroCorrection & Metaboprotection

Education:     1976 M.S. Cybernetics and Control systems, Moscow Aviation Institute.
        1983 Ph.D. (Biophysics), Moscow State University.

Professional Experience

2010-present:  Director of Research, INSERM UMR1106, Institute of System Neurosciences

Neuronal and network properties in the development of neurodegenerative diseases.

2007-2010:  Director of Research, Institut de Neurobiologie de la Méditerranée (INMED), Marseille.
Neuronal and network properties in the development ofneurodegenerative diseases.

1999-2010:  Associate Professor, Dept. of Neuroscience, Karolinska Institute, Stockholm.
Synaptic plasticity in unitary connections between neocortical neurons.

1996-1999:  Visiting Scientist, Dept. of Cell Physiology, Max-Plank-Institute for Medical
Researh, Heidelberg,  Germany.

Retrograde synaptic signaling  in unitary pyramidal cell-interneuron connections.

1991-1995:  Assistant Professor, Duke University Medical Center, NC USA.

Properties of single sodium channels in myocardial cells.
                    
1988-1991: Assistant Professor, Institute of General Pathology and Pathophysiology, Moscow.

Plasticity of glutamate receptors in cortical neurons.
        
1983-1988:  Research Associate, Vishnevsky Surgery Institute, Moscow.
Sodium currents in myocardial arrhythmias. Potassium single channels in myocardial cells.

1978-1983:     Research Assistant, Vishnevsky Surgery Institute, Moscow.
Development of the loose-patch-clamp method and studying properties of sodium currents in myocardial cells.   

General Expertise:   
Neuronal networks. Control of excitability in normal and pathological brain conditions. Ontogenesis of neuronal activities. Metabolic correction of abnormal excitability. Application to neurodegenerative diseases.

Basic biophysical parameters of neuronal activities. Biophysics of voltage-gated and receptor-operated channels; imaging and electrophysiological analysis of synaptic transmission and dendritic integration.

Main scientific achievments:
1. Development of “Loose-patch-clamp” method and its use for recordings Na currents in
    single cardiac cells (Pflugers Arch, 1982, 394,150-5; J Physiol, 1998, 511, 361-77).
2. Discovery of potentiation of glutamate-activated currents in single neurons during
    repeated stimulation (Neuron, 1990, 5, 597-602).
3. Discovery of retrograde synaptic transmission in excitatory (Neuron, 1999, 24, 979-88)
    and inhibitory (J Physiol, 2000, 528, 489-96; J Neurosci, 2004, 24, 4978-88) neocortical
    synapses.
4. Discovery of spike-timing-dependent synaptic plasticity in inhibitory neocortical
    synapses (J Neurosci, 2001, 21, 8270-7).
5. Characterization of pyramidal cell synaptic connectivity in local networks in
    neocortex (J Physiol, 2003, 551, 139-53).
6. Discovery that GABA action in neonatal neurons (excitatory or inhibitory) depends on the
    presence of energy substrates (J Neurochem, 2010, 900-912).
7. Discovery that administration of native energy substrates can reverse early pathogenesis in
    the animal model of Alzheimer’s disease (J Neurochem, 2013, 1-15 (ahead of print).

Teaching:
2001-2003:    Courses “Ionic Channels and Receptors” (regular two-week full time courses).
               Karolinska Institute, Stockholm, Sweden.    
2000-2005:    Regular lectures for undegraduate and graduate students; laboratory course
                      “Patch-clamp technique” (4 days full-time/twice each year, 2000-2005).
              Karolinska Institute, Stockholm, Sweden.    

Scientific supervising:
Supervisor and co-supervisor of 9 PhD projects.
Supervisor of more than 15 undegraduate and postdoctoral projects of scientist from Russia, USA, Germany, Sweden and France.

Invited lectures (selected from 2008 - present):
2009    - Institute of Biophysics, Pushino, Russia
    - University of Paris, France
    - University College London, England
2010    - Karolinska Institute, Stockholm, Sweden
    - Symposium “Hipocampus: Beneath the Surface”, Gien, France
2011    - University of Paris, France
    - Bar-Ilan University, Tel Aviv, Israel
    - Ben Gurion University, Beer-Sheva, Israel
    - The 21st ISFN Annual Meeting, Eilat, Israel
2012    - Institute of General Pathology and Pathophysiology, Moscow, Russia
    - Institute of Biophysics, Pushino, Russia
    - Symposium "Hippocampus and Memory", Puschino, Russia
2013    - 24th Meeting of International Society for Neuroscience, Cancun, Mexico

Editorial work:
2010-2012      “Frontiers in Neuroenergetics”, Associate editor, Review Editor
2010-current   “Frontiers in Neuropharmacology”, Associate editor, Review Editor

International cooperation (2008 – present):
Within the project “Neurobiological mechanisms of memory loss in Alzheimer's disease”
-    University of Kuopio, Finland (Prof. H. Tanila)
-    University of Szeged, Hungary (Prof. B. Penke)
-    University of Edinburg, UK (Prof. R. Morris)
-    University of Aberdeen, United Kingdom (Prof. T. Harkany)

Within the project “Metabolic management of neuronal hyperexcitability: a new approach to treat epilepsy”
-    University of Kuopio, Finland (Prof. H. Tanila)
-    Institute of Biophysics, Pushino, Russia (Prof. V. Kichigina)

Within the project “Energy substrates as a tool for treatment hyperexcitability in AD”
-    University of Kuopio, Finland (Prof. H. Tanila)
-    Institute of Biophysics, Pushino, Russia (Prof. V. Kichigina)
-    Karolinska Institute, Stockholm, Sweden (Prof. A. Fisahn)
-    University of Szeged, Hungary (Prof. B. Penke)
-    Duke University Medical Center, Durham NC, USA (Prof. D. Turner)

Research grants for the past 10 years:

2002-2004       EU Community (PI)                                           € 243,000
2003-2005      Swedish Research Council (PI)                      € 69,000
2004            Swedish Research Council Equipment           € 385,000
2005         OTAN (PI)                                                     € 19,800
2006-2007      Swedish Research Council (PI)              € 59,000  
2007-2010    Agence Nationale de la Recherche        € 100,000
2008-2012    NIH                         $ 195,000    
2008-2012    EU Community,  PF-7 (PI)            € 514,000
20011-2014    Agence Nationale de la Recherche    (PI)    € 337,000
2012-2015       American Association for Alzheimer’s          $394,000
                        Disease  (PI)                                                          

Publications:

ISI Web of Knowledge selected 61 articles with the following results:
Total number of citations: 1447
Average number of citations/article 24.21
h-index 29

10 most cited articles:

  1. Holmgren, C., Harkany, T., Svennenfors, B. and Zilberter, Y. (2003) Pyramidal cell communication within local networks in layer 2/3 of rat neocortex. J Physiol, 551, 139-153.       Cited 152 times.
  2. Zilberter, Y., Kaiser, K. M. and Sakmann, B. (1999) Dendritic GABA release depresses excitatory transmission between layer 2/3 pyramidal and bitufted neurons in rat neocortex. Neuron, 24, 979-988. Cited 98 times.
  3. Zilberter, Y. (2000) Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortex. J Physiol, 528, 489-496. Cited 83 times.
  4. Minkeviciene, R., Rheims, S., Dobszay, M. B., Zilberter, M., Hartikainen, J., Fülöp, L., Penke, B., Zilberter, Y., Harkany, T., Pitkänen, A. and Tanila, H. (2009) Fibrillar β-amyloid-induced hyperexcitability of cortical and hippocampal neurons triggers progressive epilepsy. J Neurosci, 29, 3453-3462. Cited 69 times.
  5. Rozov, A., Zilberter, Y., Wollmuth, L. P. and Burnashev, N. (1998) Facilitation of currents through rat Ca2+-permeable AMPA receptor channels by activity-dependent relief from polyamine block. J Physiol, 511 ( Pt 2), 361-377. Cited 68 times.
  6. Harkany, T., Holmgren, C., Hartig, W., Qureshi, T., Chaudhry, F. A., Storm-Mathisen, J., Dobszay, M. B., Berghuis, P., Schulte, G., Sousa, K. M., Fremeau, R. T., Jr., Edwards, R. H., Mackie, K., Ernfors, P. and Zilberter, Y. (2004) Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. J Neurosci, 24, 4978-4988.
  7.             Cited 63 times.
  8. Holmgren, C. D. and Zilberter, Y. (2001) Coincident spiking activity induces long-term changes in inhibition of neocortical pyramidal cells. J Neurosci, 21, 8270-8277.
  9.             Cited 62 times.
  10. Zilberter, Y., Burnashev, N., Papin, A., Portnov, V. and Khodorov, B. (1988) Gating kinetics of ATP-sensitive single potassium channels in myocardial cells depends on electromotive force. Pflugers Arch, 411, 584-589. Cited 59 times.
  11. Starmer, C. F., Romashko, D. N., Reddy, R. S., Zilberter, Y. I., Starobin, J., Grant, A. O. and Krinsky, V. I. (1995) Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias. Circulation, 92, 595-605.
  12.             Cited 55 times.
  13. Starobin, J. M., Zilberter, Y. I., Rusnak, E. M. and Starmer, C. F. (1996) Wavelet formation in excitable cardiac tissue: the role of wavefront-obstacle interactions in initiating high-frequency fibrillatory-like arrhythmias. Biophys J, 70, 581-594.
  14.             Cited 49 times.

Selected publications from 2008

  1. Ivanov, A., Tyzio, R., Zilberter, Y. and Ben-Ari, Y. (2008) (R)-roscovitine, a cyclin-dependent kinase inhibitor, enhances tonic GABA inhibition in rat hippocampus. Neuroscience, 156, 277-288
  2. Rheims, S., Minlebaev, M., Ivanov, A., Represa, A., Khazipov, R., Holmes, G. L., Ben-Ari, Y. and Zilberter, Y. (2008) Excitatory GABA in Rodent Developing Neocortex In Vitro. J Neurophysiol, 100, 609-619.
  3. Rheims, S., Represa, A., Ben-Ari, Y. and Zilberter, Y. (2008) Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses. J Neurophysiol, 100, 620-628.
  4. Minkeviciene, R., Rheims, S., Dobszay, M. B., Zilberter, M., Hartikainen, J., Fülöp, L., Penke, B., Zilberter, Y., Harkany, T., Pitkänen, A. and Tanila, H. (2009) Fibrillar β-amyloid-induced hyperexcitability of cortical and hippocampal neurons triggers progressive epilepsy. J Neurosci, 29, 3453-3462.
  5. Rheims, S., Holmgren, C. D., Chazal, G., Mulder, J., Harkany, T., Zilberter, T. and Zilberter, Y. (2009) GABA action in immature neocortical neurons directly depends on the availability of ketone bodies. J Neurochem, 110, 1330-1338.
  6. Zilberter, M., Holmgren, C., Shemer, I., Silberberg, G., Grillner, S., Harkany, T. and Zilberter, Y. (2009) Input specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cells. Cereb Cortex, 19, 2308-2320.
  7. Holmgren, C. D., Mukhtarov, M., Malkov, A. E., Popova, I. Y., Bregestovski, P. and Zilberter, Y. (2010) Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro. J Neurochem, 112, 900-912.
  8. Zilberter, Y., Zilberter, T. and Bregestovski, P. (2010) Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis. Trends Pharmacol Sci, 31, 394-401.
  9. Ivanov, A., Mukhtarov, M., Bregestovski, P. and Zilberter, Y. (2011) Lactate effectively covers energy demands during neuronal network activity in neonatal hippocampal slices. Frontiers in Neuroenergetics, 3, 1-14.
  10. Ivanov, A. and Zilberter, Y. (2011) Critical state of energy metabolism in brain slices: the principal role of oxygen delivery and energy substrates in shaping neuronal activity. Front Neuroenergetics, 3, 9.
  11. Mukhtarov, M., Ivanov, A., Zilberter, Y. and Bregestovski, P. (2011) Inhibition of spontaneous network activity in neonatal hippocampal slices by energy substrates is not correlated with intracellular acidification. J Neurochem, 116, 316-321.
  12. Zilberter, Y. (2012) Understanding how the brain ensures its energy supply. Front Neuroenergetics, 4, 9.
  13. Bregestovski, P.; Zilberter, Yu. (2012) Ion homeostasis, energy substrates, and network activity in developing brain. Biologicheskie Membrany, 29, 51-58.
  14. Zilberter, Yu.; Bregestovski, P. (2012) Fueling brain neuronal activity. Biologicheskie
  15.             Membrany, 29, 59-64.
  16. Zilberter, M., Ivanov, A., Ziyatdinova, S., Mukhtarov, M., Malkov, A., Alpar, A., Tortoriello, G., Botting, C. H., Fulop, L., Osypov, A. A., Pitkanen, A., Tanila, H., Harkany, T. and Zilberter, Y. (2013) Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease. J Neurochem, (ahead of print) DOI 10.1111/jnc.12127.