PhysioNet Team Member

Pascale Quilichini

Pascale Quilichini, Postdoc
PhysioNet


Email:

Phone number:
+33 4 91 29 98 08

I am a postdoc fellow in PhysioNet team since October 2009 and I am responsible of the In Vivo group in PhysioNet.

Research Activities :

I currently investigate the interactions between the temporal lobe (entorhinal cortex and hippocampus), the thalamus (nucleus reuniens) and prefrontal cortex in physiological conditions as well as in models of temporal lobe epilepsy. Specifically, my goal is to map the inner dynamics, the communication and the functional connectivity among these networks in order to decipher the mechanisms supporting the mnesic function and the construction of epileptic networks (emergence of seizures, associated cognitive co-morbidities..).

Sans titre - 1

We use silicon probe recordings technology in anaesthetised and freely-moving animals. In collaboration with BEL Lab, we do also develop new bioelectronic devices for long lasting, 100% biocompatible and high-resolution recordings in depth and on the brain's surface.

  

In Vivo Group:
- Ana F. Vincente (Postdoc)
- Antoine Ghestem (AI AMU)
- Maeva Ferraris (PhD Student)
- Andrea Slézia (Postdoc) 
Huifang Wang (Postdoc)
- myself :)

 

 Resume:
- PhD in Neuroscience (2005), INMED INSERM U29 ; Université de la Méditerranée, Marseille, France.
- Master Degree in Cellular Biology, Physiology & Neuroscience (2001); Université de la Méditerranée; Marseille, France.
- B.S. in Physical chemistry (1999) Université de Provence; Marseille, France.
- Baccalauréat in mathematics and biology(1995) Académie d’Aix-Marseille, France.

 

Past Research Activities :
2005-2009 Postoctorant fellow in CMBN, Rutgers University, NJ, USA ; PI: György Buzsáki
2000-2005 PhD student at INSERM U29 INMED, Marseille ; PI : Yehezkel Ben-Ari

 

Publications:

Williamson A, Ferro M, Leleux P, Ismailova E, Kaszas A, Doublet T, Quilichini P, Rivnay J, Rózsa B, Katona G, Bernard C, Malliaras GG (2015) Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes. Adv Mater.

Wang HE, Bénar CG, Quilichini PP, Friston KJ, Jirsa VK, Bernard C (2014) A systematic framework for functional connectivity measures. Front Neurosci. 8:405.

Jirsa VK, Stacey WC, Quilichini PP, Ivanov AI, Bernard C (2014) On the nature of seizure dynamics.
Brain;137(Pt 8):2210-30.

Khodagholy D, Doublet T, Quilichini PP, Gurfinkel M, Leleux P, Ghestem A, Ismailova E, Herve T, Sanaur S, Bernard C, Malliaras Gg. (2013) In vivo recordings of brain activity using organic transistors. Nature Communications, 4:1575.

Quilichini PP, Bernard C. (2012) Brain state-dependent neuronal computation. Front Comp Neuro, 6 (77) :1-7.

Quilichini PP, Le Van Quyen M, Ivanov A, Turner DA, Carabanola A, Esclapez M, Bernard C. (2012) Hub GABA Neurons Mediate Gamma-Frequency Oscillations at Ictal-like Event Onset in the Immature Hippocampus Neuron, 74: 57-64.

Quilichini PP, Bernard C. (2012) Brain state-dependent neuronal computation. Front Comp Neuro, 6 (77) :1-7.

Adhikari M, Quilichini PP, Roy Dm, Jirsa V, Bernard C. (2012) Brain state dependent post inhibitory rebound in entorhinal cortex interneurons. Journal of Neuroscience 32: 6501-6510.

Khodagholy D, Doublet T, Gurfinkel M, Quilichini PP, Ismailova E, Leleux P, Herve T, Sanaur S, Bernard C, Malliaras GG (2011) Highly conformable conducting polymer electrodes for in vivo recordings. Adv Materials, 23(36):H268-72 .

Ismailova E, Doublet T, Khodagholy D, Quilichini PP, Ghestem A, Yang Sy, Bernard C, Malliaras GG (2011) Plastic neuronal probes for implantation in cortical and subcortical areas of the rat brain. Int. J. Nanotechnol. Vol 8, Nos 10-12.

Quilichini Pp, Sirota A, Buzsaki G (2010) Intrinsic circuit organization and theta-gamma oscillation dynamics in the entorhinal cortex of the rat. J Neurosci. 30 :11128-42 (IF: 7.27)

Chuquet J, Quilichini PP, Nimchinsky Ea, Buzsaki G (2010) Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex. J Neurosci. 30: 15298-303.

Quilichini PP, Chiron C, Ben Ari Y, Gozlan H (2006) Stiripentol, a putative antiepileptic drug, enhances GABA release and GABAA receptor channels open duration. Epilepsia 47(4): 704-716.

Quilichini PP, Diabira D, Chiron C, Ben Ari Y, Gozlan H (2002) Persistent epileptiform activity induced by low Mg2+ in intact immature brain structures. Eur J Neurosci 16: 850-860. (IF: 3.658)

Quilichini PP, Diabira D, Chiron C, Milh M, Ben Ari Y, Gozlan H (2003) Effects of antiepileptic drugs on refractory seizures in the intact immature cortico-hippocampal formation in vitro. Epilepsia 44(11): 1365-1374.

 

Awards:

  • 2011-2012: CURE (Citizens United for Research in Epilepsy) USA; Taking Flight Award, PI : P. Quilichini @ INSERM U1106. 
  • 2011: LFCE (Ligue Française Contre l’Epilepsie) ; Postdoc grant (1 y.), PI : P. Quilichini @ INSERM U1106
  • 2009: FRM (Fondation pour la Recherche Médicale); Postdoc grant (2 y.) « back to France », PI : P. Quilichini @ INSERM U751 (U1106 previous id)
  • 2009: FFRE (Fédération Française pour la Recherche sur l’Epilepsie); Equipment grant, PI : P. Quilichini @ INSERM U751
  • 2007: Epilepsy Foundation USA; Postdoc grant (1 y.), PI : P. Quilichini @ CMBN Rutgers University
  • 2006: IBRO (International Brain Research Organization) ; Postdoc grant (1 y.), PI : P. Quilichini @ CMBN Rutgers University
  • 2005: Philip Foundation ; Postdoc price, PI : P. Quilichini @ CMBN Rutgers University
  • 2005: FRM ; Postdoc grant (1 y.) « going abroad », PI : P. Quilichini @ CMBN Rutgers University
  • 2004: LFCE ; PhD grant (1 y.) @ INSERM U29
  • 2002: Laboratoires Biocodex ; PhD grant (2 y.) @ INSERM U29
  • 2001: FFRE ; PhD grant (1 y.) @ INSERM U29