INS Keynote Seminar – Sylvain Baillet (Montreal)
« Possible mechanisms underlying the polyrhythmic activity of the brain: from rest to perception. »
One broad objective in neuroscience is to comprehend the mechanisms of large-scale, oscillatory neural dynamics: how they enable functions by shaping communication in brain networks, and how the earliest detection of their alterations in disease can contribute to improved healthcare prevention and interventions. To contribute toward this goal, our approach is to combine imaging methods and experimental neuroscience with computational and disease models, neuromodulation techniques, and translational arms to the clinic and industry. Our rationale is that the ubiquitous polyrhythmic activity of the brain has been approached empirically, with underlying mechanisms that remain not understood.
This hinders our comprehension of how 1) perception and behaviour emerge from brain network activity, and 2) the pathophysiological developments of brain and mental-health disorders increasingly studied as network diseases, affect large-scale neural communication.
These difficult questions require a bottom-up approach: We aim to understand how basic physiological factors of neural integrity and function shape the dynamical structure of oscillatory brain rhythms, such as their interdependence across multiple frequencies through cross-frequency coupling. These phenomena represent a deep source of uncharted markers of neural excitability, activity and connectivity. I will illustrate these principles with our latest results concerning the resting brain, multimodal perception and pathophysiological markers of epilepsy and neurodegenerative syndromes.
For any question, feel free to contact:
Demian Battaglia (firstname.lastname@example.org) or Benjamin Morillon (email@example.com)